Orbiter structural design and verification

The space shuttle development program provided the opportunity to challenge many of the established practices and approaches used in prior manned space flight programs. The most significant accomplishments and resulting precedents which emerged during the structural development of the space shuttle and the space shuttle orbiter are reviewed. Innovations in criteria, design solutions, and certification are highlighted, and brief comments on the lessons learned are included. Thermal stress, graphite epoxy moisture, window structure, and structural inspection are discussed under lessons learned

Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones

Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood. The differentiation of stem cells after leaving their niches depends predominately on the local milieu and its new microenvironment, and is facilitated by soluble factors but also by the close cell-cell interaction in a three-dimensional tissue or organ system. We have isolated CD34-negative, mesenchymal stem cell lines from human bone marrow and peripheral blood and generated monoclonal cell populations after immortalization with the SV40 large T-antigen. The cultivation of those adult stem cell clones in an especially designed in vitro environment, including self-constructed glass capillaries with defined growth conditions, leads to the spontaneous establishment of pleomorphic three-dimensional cell aggregates ( spheroids) from the monoclonal cell population, which consist of cells with an osteoblast phenotype and areas of mineralization along with well-vascularized tissue areas. Modifications of the culture conditions favored areas of bone-like calcifications. After the transplantation of the at least partly mineralized human spheroids into different murine soft tissue sites but also a dorsal skinfold chamber, no further bone formation could be observed, but angiogenesis and neovessel formation prevailed instead, enabling the transplanted cells and cell aggregates to survive. This study provides evidence that even monoclonal adult human CD34-negative stem cells from the bone marrow as well as peripheral blood can potentially differentiate into different mesenchymal tissues depending on the local milieu and responding to the needs within the microenvironment. Copyright (C) 2005 S. Karger AG, Basel

A few things I learnt from Jurgen Moser

A few remarks on integrable dynamical systems inspired by discussions with Jurgen Moser and by his work.Comment: An article for the special issue of "Regular and Chaotic Dynamics" dedicated to 80-th anniversary of Jurgen Mose

Spiral phases and two-particle bound states from a systematic low-energy effective theory for magnons, electrons, and holes in an antiferromagnet

We have constructed a systematic low-energy effective theory for hole- and electron-doped antiferromagnets, where holes reside in momentum space pockets centered at $(\pm\frac{\pi}{2a},\pm\frac{\pi}{2a})$ and where electrons live in pockets centered at $(\frac{\pi}{a},0)$ or $(0,\frac{\pi}{a})$. The effective theory is used to investigate the magnon-mediated binding between two holes or two electrons in an otherwise undoped system. We derive the one-magnon exchange potential from the effective theory and then solve the corresponding two-quasiparticle Schr\"odinger equation. As a result, we find bound state wave functions that resemble $d_{x^2-y^2}$-like or $d_{xy}$-like symmetry. We also study possible ground states of lightly doped antiferromagnets.Comment: 2 Pages; Proc. of SCES'07, Housto